The master output is distorted or clipping noise is heard.

Does the Limiter illuminate in the upper right of the GUI?

When the Limiter is activated to prevent clipping, these problems can occur.

Then, turn the master volume down to a level at which the Limiter is not illuminated.

If turning down the master volume does not solve the problem, increase the [USB BUFFER SIZE] setting at [SETUP] > [HARDWARE].